- Tetra capsule 250 – 500 mg, 16 capsules
Composition
Each capsule contains 250-500 mg tetracycline HCI.
Features
- A wide - spectrum antibiotic
- Has bacteriostatic effect and exerts this effect by inhibiting protein synthesis of microorganisms.
- Absorbed readily through the gastrointestinal tract.
- Shortly distributed into body tissues and fluids in effective concentrations.
- Readily crosses the hematoencephalic barrier.
Spectrum of Activity
Effective against bacteria such as staphylococci, streptococci, Diplococcus pneumoniae, Haemophilus influenzae, Escherichia coli, Enterobacter aerogenes, Chlamydia trachomatis, Shigella, Mima, Herellia and Klebsiella and also to Rickettsiae, some Protozoas and Psittacosis-lymphogranuloma group of viruses. Penicillin-resistant Neisseria gonorrhoeae, Treponema pallidium, Listeria monocytogenes, Clostridia, Bacillus anthracis, Fusobacterium fusiforme and Actinomyces strains are also included in its spectrum of activity.
Indications
The following infections caused by susceptible organisms:
- ENT and lower respiratory tract infections
- Urinary tract infections
- Penicillin - resistant gonorrhea, syphilis
- Endocervical and rectal infections
- Skin and soft- tissue infections
- Acne, diphteria, scarlet fever
- Dysenteria
- Brucellosis, typhus, trachoma
- Acute anthrax
- Rickettsia infections
- Actinomycosis, mastoiditis
- Pre - and post - surgical prophylaxis.
Contraindications
Is contraindicated in individuals known to be hypersensitive to tetracyclines.
Warnings and Precautions
- It should be taken with plenty of water to prevent gastrointestinal side effects.
- It should not be used in the last half of pregnancy and in children up to 8 years old because of its potential for tooth discoloration.
Adverse Reactions
Mild nausea, vomiting, softening of feces, and sometimes diarrhea can be seen in sensitive patients. Photosensitivity can occur. Use of tetracycline - group of preparations during tooth development can cause permanent discoloration of the teeth.
Drug Interactions
Since they interfere with its absorption, Tetra capsule should not be used concomitantly with aluminum - containing antacids, magnesium - containing laxatives, iron - containing antianemia preparations. A decrease in the dose of anticoagulant agent can be required in patients on anticoagulant therapy.
Dosage and Administration
Adults: 1-2 g/day, given at 6 hour intervals
Children: 25 mg/kg/day, given at 6 hour intervals.
In streptococcal infections treatment should be given for at least 10 days.
In urethral, endocervical and rectal infections caused by C. trachomatis, Tetra capsule should be given 500 mg qid for at least 7 days.
In the treatment of gonorrhea caused by N. gonorrhoeae, following a 1.5 g loading dose, Tetra capsule should be administered 500 mg every 6 hours until a total dose of 9 g is completed (4 days).
In the treatment of brucellosis, Tetra capsule 500 mg should be given every 6 hours for a period of 3 weeks. In skin and soft - tissue infections, Tetra capsule 250 mg administered every 6 hours is adequate.
In the treatment of syphilis, a total of 30-40 g Tetra should be given in 4 equally divided doses for a period of 10 to 15 days.
Storage Conditions
Should be kept out of reach of children, at room temperature (< 25ºC) and in its package.
Available Forms
TETRA capsule 250-500 mg; 16-capsule blister packs.
